Universität Wien
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250054 VO Probabilistic Models in Biomathematics (2021S)

5.00 ECTS (3.00 SWS), SPL 25 - Mathematik

Registration/Deregistration

Note: The time of your registration within the registration period has no effect on the allocation of places (no first come, first served).

Details

Language: English

Examination dates

Lecturers

Classes (iCal) - next class is marked with N

https://zoom.us/j/9173785622?pwd=VnUzSStFUHVvU3c0YlFqNEZhb29ydz09

ID de réunion : 917 378 5622
Code secret : mE6M9t

  • Monday 01.03. 15:00 - 17:15 Digital
    Seminarraum 9 Oskar-Morgenstern-Platz 1 2.Stock
  • Monday 08.03. 15:00 - 17:15 Digital
    Seminarraum 9 Oskar-Morgenstern-Platz 1 2.Stock
  • Monday 15.03. 15:00 - 17:15 Digital
    Seminarraum 9 Oskar-Morgenstern-Platz 1 2.Stock
  • Monday 22.03. 15:00 - 17:15 Digital
    Seminarraum 9 Oskar-Morgenstern-Platz 1 2.Stock
  • Monday 12.04. 15:00 - 17:15 Digital
    Seminarraum 9 Oskar-Morgenstern-Platz 1 2.Stock
  • Monday 19.04. 15:00 - 17:15 Digital
    Seminarraum 9 Oskar-Morgenstern-Platz 1 2.Stock
  • Monday 26.04. 15:00 - 17:15 Digital
    Seminarraum 9 Oskar-Morgenstern-Platz 1 2.Stock
  • Monday 03.05. 15:00 - 17:15 Digital
    Seminarraum 9 Oskar-Morgenstern-Platz 1 2.Stock
  • Monday 10.05. 15:00 - 17:15 Digital
    Seminarraum 9 Oskar-Morgenstern-Platz 1 2.Stock
  • Monday 17.05. 15:00 - 17:15 Digital
    Seminarraum 9 Oskar-Morgenstern-Platz 1 2.Stock
  • Monday 31.05. 15:00 - 17:15 Digital
    Seminarraum 9 Oskar-Morgenstern-Platz 1 2.Stock
  • Monday 07.06. 15:00 - 17:15 Digital
    Seminarraum 9 Oskar-Morgenstern-Platz 1 2.Stock
  • Monday 14.06. 15:00 - 17:15 Digital
    Seminarraum 9 Oskar-Morgenstern-Platz 1 2.Stock
  • Monday 21.06. 15:00 - 17:15 Digital
    Seminarraum 9 Oskar-Morgenstern-Platz 1 2.Stock
  • Monday 28.06. 15:00 - 17:15 Digital
    Seminarraum 9 Oskar-Morgenstern-Platz 1 2.Stock

Information

Aims, contents and method of the course

This class will cover several probabilistic models arising in biomathematics, with a particular focus on population genetics. One of the major challenge of population genetics is the inference of the evolutionary history of a population (or a species) from the observation of its extant genetic diversity. From a mathematical point of view, the approach consists in starting from tractable models in order to make theoretical predictions on the genetic signature of various evolutionary scenarii: natural selection, mutation, demography (i.e. migration, population expansion etc.), pure genetic drift or recombination.
In this course, I will introduce several of the aforementioned probabilistic models and introduce various technics to analyse them. I will start from the Wright-Fisher diffusion(s) describing the evolution of the genetic composition in large populations. I will show that an efficient way to analyse such models relies on the description of their underlying genealogical structure. More precisely, if several individuals are sampled from an extent population, one can trace backward in time the genealogical lines of those individuals. I will show how coalescent theory (Kingman coalescent, $\Lamda$-coalescents) provides an elegant description of this genealogy, and how it allows to draw predictions on the genetic structure of large populations.
If time permits, I will also show how the previous approaches can be carried through in epidemiogy in order to describe a viral expansion (Feller diffusion) and its underlying genealogical structure of such a population (coalescent point processes).
Along the way, I hope to introduce general probabilistic concepts which will be of independent interest : martingales, duality, exchangeability etc.

Assessment and permitted materials

Minimum requirements and assessment criteria

Strong undergraduate probability. Some knowledge on the following topics: Stochastic processes, Markov processes (discrete and continuous time), Brownian motion, diffusions. No knowledge of measure theory will be required.

Art der Leistungskontrolle und erlaubte Hilfsmittel
Two graded home-works will be assigned during the semester. The final exam will be an oral exam (duration to be determined).

Examination topics

Will be distributed by email.

Reading list

Will be distributed by email

Association in the course directory

MBIV

Last modified: Fr 12.05.2023 00:21