Universität Wien
Warning! The directory is not yet complete and will be amended until the beginning of the term.

270107 VO Stereoselective Drug Analysis (and clinical applications) (2010W)

1.50 ECTS (1.00 SWS), SPL 27 - Chemie

Donnerstag, 28.10.2010;
Dienstag 02.11.2010;
Donnerstag, 04.11.2010;
Donnerstag 11.11.2010;
Donnerstag 18.11.2010;
Donnerstag, 25.11.2010;

jeweils 18:00-19:30 Uhr
Ort: Seminarraum Analytische Chemie

Details

Language: German

Examination dates

Lecturers

Classes

Currently no class schedule is known.

Information

Aims, contents and method of the course

Content: Basic principles of stereochemistry (nomenclature, chiral elements); Impact of stereochemistry on biological action; Stereochemistry of drug-protein interaction; Stereo-selectivity in pharmacodynamics; Stereoselectivity in pharmacokinetics including pharmacogenetics; Concepts of enantiomer separation; Indirect liquid chromatographic enantiomer separation; Enantioselective capillary electrophoresis (CE) and chiral selectors for CE; Direct liquid chromatographic enantiomer separation including discussion of chiral stationary phases; Gas chromatographic enantiomer separation; Applications of enantiomer separation methods.
Supporting material: Slides of presentation

Assessment and permitted materials

Minimum requirements and assessment criteria

Principles of stereochemistry, impact on biological action

Examination topics

Evaluation: oral examination

Reading list

The Impact of Stereochemistry on Drug Development and Use. H. Y.
Aboul-Enein, I.W. Wainer (Eds.), J. Wiley, New York, 1997.
Recent developments in liquid chromatographic enantioseparation.
M. Lämmerhofer, W. Lindner
In: Handbook of analytical separations, Vol. 1 (Separation methods in
drug synthesis and purification), Elsevier, Amsterdam, 337-437
Separation of enantiomers: needs, challenges, perspectives.
N. M. Maier, P. Franco, W. Lindner
J. Chromatogr. A, 906 (1-2), 3-33.
Stereoselective chromatographic methods for drug analysis.
N. M. Maier, W. Lindner
In: Methods and Principles in Medicinal Chemistry, Vol. 33, 189-260.
Chiral Chromatography.
Michael Laemmerhofer, topic owner/topic chapter in:CHROMEDIA - A web
Infotope for the Practicing Chromatography Community (peer reviewed web
communication). http://www.chromedia.nl/

Association in the course directory

AN-2; CHE II-1.

Last modified: We 19.08.2020 08:06