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300308 VO Human Evolutionary Genetics: genomic, genes, diseases (2024S)

3.00 ECTS (2.00 SWS), SPL 30 - Biologie
Moodle

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Details

Language: English

Examination dates

Lecturers

Classes (iCal) - next class is marked with N

  • Monday 04.03. 15:00 - 16:30 Hörsaal 3, Biologie Djerassiplatz 1, 0.005, Ebene 0
  • Monday 11.03. 15:00 - 16:30 Hörsaal 3, Biologie Djerassiplatz 1, 0.005, Ebene 0
  • Monday 18.03. 15:00 - 16:30 Hörsaal 3, Biologie Djerassiplatz 1, 0.005, Ebene 0
  • Monday 08.04. 15:00 - 16:30 Hörsaal 3, Biologie Djerassiplatz 1, 0.005, Ebene 0
  • Monday 15.04. 15:00 - 16:30 Hörsaal 3, Biologie Djerassiplatz 1, 0.005, Ebene 0
  • Monday 22.04. 15:00 - 16:30 Hörsaal 3, Biologie Djerassiplatz 1, 0.005, Ebene 0
  • Monday 29.04. 15:00 - 16:30 Hörsaal 3, Biologie Djerassiplatz 1, 0.005, Ebene 0
  • Monday 06.05. 15:00 - 16:30 Hörsaal 3, Biologie Djerassiplatz 1, 0.005, Ebene 0
  • Monday 13.05. 15:00 - 16:30 Hörsaal 3, Biologie Djerassiplatz 1, 0.005, Ebene 0
  • Monday 27.05. 15:00 - 16:30 Hörsaal 3, Biologie Djerassiplatz 1, 0.005, Ebene 0
  • Monday 03.06. 15:00 - 16:30 Hörsaal 3, Biologie Djerassiplatz 1, 0.005, Ebene 0
  • Monday 10.06. 15:00 - 16:30 Hörsaal 3, Biologie Djerassiplatz 1, 0.005, Ebene 0
  • Monday 17.06. 15:00 - 16:30 Hörsaal 3, Biologie Djerassiplatz 1, 0.005, Ebene 0

Information

Aims, contents and method of the course

The aim of this lecture is to provide students with knowledge and a good understanding of the scientific field of human genetics. The lectures will also prepare students in particular to understand how different evolutionary forces influence the human genome. Students learn about the key concepts of human evolutionary genetics and gain insights into how genetics/genomics can be used to elucidate the phenotypic traits such as diseases, immune defences and behaviour.
The first part of the lectures introduces students to the structure of the human genome, the key aspects of chromosome biology; the basis of gene functions and the role of epigenetics in gene regulation. In the second part, students will be briefly introduced to the state-of-the-art methods used in human genomics. The third part of the lecture is designed to provide an understanding of the fundamentals and methods of evolutionary and population genetics and molecular anthropology. Students will gain insight into how different evolutionary processes affect human genomic diversity and learn how these concepts are used to understand genetic diversity at both the individual and population levels. In the fourth part, students will gain understanding how human genomic variation can directly or indirectly affect the risk to develop diseases, contribute to host defence, and influences human behaviours. (Research-focused lectures providing case-studies).
Teaching and learning methods: Lectures, handouts, and presentations (PowerPoint slides will be provided on Moodle).

Assessment and permitted materials

For a positive evaluation of the final exam, 50% of the exam questions must be answered correctly. Calculators may be used as aids.

Minimum requirements and assessment criteria

Student should gain knowledge and understanding:
i) human genomics, chromosome biology and heredity;
ii) gene function, regulation, and transcription;
iii) role of epigenetic modification in gene regulation;
iv) molecular methods used in human genetics/genomics;
v) key concepts of human evolutionary- and population genetics; molecular anthropology
vi) understanding human genomic variation and function in human health, disease and behavior;
vii) applying the gained knowledge to research questions/problems.
For a positive grade, at least 50% of the exam questions must be answered correctly.

Examination topics

Lectures and presentations (course content).

Textbooks:
Human Evolutionary Genetics (2013, 2nd ed.). Mark A. Jobling et al.
An Introduction to Molecular Anthropology (2016). Mark Stoneking.
Human Molecular Genetics (2018, 5th ed.). Tom Strachan & Andrew Read

Reading list

Human Evolutionary Genetics
Mark A. Jobling, Edward Hollox , Mathew Hurles, Toomas Kivisild, Chris Tyler-Smith.
Publication Date: June 25, 2013 | ISBN-10: 0815341482 | ISBN-13: 978-0815341482 | Edition: 2

An Introduction to Molecular Anthropology
Mark Stoneking
ISBN: 978-1-118-06162-6 December 2016 Wiley-Blackwell

Human Molecular Genetics (5th ed.)
Tom Strachan & Andrew Read
Publication Date: December, 2018 | · ISBN-13: 9780815345893 | Edition: 5

The Princeton Guide to Evolution
Jonathan B. Losos (editor in chief), David A. Baum, Douglas J. Futuyma, Hopi E. Hoekstra, Richard E. Lenski, Allen J. Moore, Catherine L. Peichel, Dolph Schluter & Michael C. Whitlock (editors). Publication Date: 2013, ISBN: 9780691149776. eBook ISBN: 9781400848065

Association in the course directory

UF BU 10, BAN 2, BMG 10, BMB 10

Last modified: We 31.07.2024 12:06