300693 VO Applied Macromolecular Crystallography (2007W)
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MMB II-2, M205
Last modified: Fr 31.08.2018 08:57
macromolecular X-ray crystallography.The following topics will be covered:
* sources of X-rays
* crystallisation techniques
* symmetry (point groups, space groups), unit cell, Bravais lattice
* scattering of X-rays, atomic form factor, structure factor
* waves, diffraction on molecules and crystals, Fourier transform; electron density
* set-up of MX diffraction experiment and detectors
* methods for solution of phase problem: molecular replacement, multiple isomorphous replacement, multi-wavelength anomalous dispersion
* density modification techniques
* structure refinement and structural analysis.