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320003 VO Biophysical Pharmaceutical Chemistry (2008W)
Labels
Beginn: 29.10., 11:00, Hs 4;
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Prüfungstermine:
Stoffsemester 2008: 30.1., 13:00, Hs 7; 6.3., 11:30, Hs8; 3.4., 13:30, Hs 6; 14.5., 11:30, Hs 8; 16.6., 11:30, Hs 8; 8.7., 10:00, Hs 8; 29.9., 10:00, Hs 6;
Bitte für die e-learning Plattform anmelden!
Prüfungstermine:
Stoffsemester 2008: 30.1., 13:00, Hs 7; 6.3., 11:30, Hs8; 3.4., 13:30, Hs 6; 14.5., 11:30, Hs 8; 16.6., 11:30, Hs 8; 8.7., 10:00, Hs 8; 29.9., 10:00, Hs 6;
Details
Information
Aims, contents and method of the course
the thermodynamic basis for interaction of drugs with biomolecules; interaction forces involved in drug-biomolecule interaction (ionic-, dipol-dipol-, electronendonor/acceptor-, hydrophobic-, Van der Waals-interactions, hydrogen bonding) and methods to measure these forces (microcalorimetrie, ORCD, binding studies), determination of the structure of ligand-protein complexes (X-ray crystallography, NMR-spectroscopy), strategies for identification of lead-compounds (serendipity, transition state mimicry, high throughput screening, in silico screening), optimisation of lead compounds - rational drug design (statistical background, 2D- and 3D- structure activity relationship analysis, methods used in quantitative structure activity relationship studies), structure based design (docking, SAR by NMR, de novo design)
Assessment and permitted materials
Written exam, 10 questions, 100 points, 90 minutes
Minimum requirements and assessment criteria
The lecture gives an overview on the theoretical background and the experimental biophysical methods for the rational design of new drugs. Main topics are the molecular basis of drug-receptor interaction, methods for measuring the corresponding interaction forces and the use of these data in computational drug design.
Examination topics
Language: German (material partly in English); powerpoint presentation, software demonstrations
Reading list
Association in the course directory
A210
Last modified: Fr 31.08.2018 08:57