Universität Wien
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320003 VO Biophysical Pharmaceutical Chemistry (2013W)

4.00 ECTS (2.00 SWS), SPL 32 - Pharmazie

Prüfungstermine:
09.07.2014 10.00 Uhr HS 8
17.09.2014 10.00 Uhr HS 8

Mo 09.00-10.30 Uhr (von 28.10. - 16.12.2013 im HS 4 ab 13.01.2014 im HS 5)!!!

Prüfungstermine:
30.01.2014 12.30 Uhr HS 6
12.02.2014 12.00 Uhr HS 6
20.02.2014 12.00 Uhr HS 6
03.03.2014 10.30 Uhr HS 6
10.04.2014 12.00 Uhr HS 6
14.05.2014 10.30 Uhr HS 6
17.06.2014 14.00 Uhr HS 6

Moodle

Details

Language: German

Examination dates

Lecturers

Classes (iCal) - next class is marked with N

  • Thursday 24.10. 10:30 - 12:00 UZA2 Hörsaal 4 (Raum 2Z221) 2.OG
  • Monday 28.10. 09:00 - 10:30 UZA2 Hörsaal 4 (Raum 2Z221) 2.OG
  • Thursday 31.10. 10:30 - 12:00 UZA2 Hörsaal 4 (Raum 2Z221) 2.OG
  • Monday 04.11. 09:00 - 10:30 UZA2 Hörsaal 4 (Raum 2Z221) 2.OG
  • Thursday 07.11. 10:30 - 12:00 UZA2 Hörsaal 4 (Raum 2Z221) 2.OG
  • Monday 11.11. 09:00 - 10:30 UZA2 Hörsaal 4 (Raum 2Z221) 2.OG
  • Thursday 14.11. 10:30 - 12:00 UZA2 Hörsaal 4 (Raum 2Z221) 2.OG
  • Monday 18.11. 09:00 - 10:30 UZA2 Hörsaal 4 (Raum 2Z221) 2.OG
  • Thursday 21.11. 10:30 - 12:00 UZA2 Hörsaal 4 (Raum 2Z221) 2.OG
  • Monday 25.11. 09:00 - 10:30 UZA2 Hörsaal 4 (Raum 2Z221) 2.OG
  • Thursday 28.11. 10:30 - 12:00 UZA2 Hörsaal 4 (Raum 2Z221) 2.OG
  • Monday 02.12. 09:00 - 10:30 UZA2 Hörsaal 4 (Raum 2Z221) 2.OG
  • Thursday 05.12. 10:30 - 12:00 UZA2 Hörsaal 4 (Raum 2Z221) 2.OG
  • Thursday 12.12. 10:30 - 12:00 UZA2 Hörsaal 4 (Raum 2Z221) 2.OG
  • Monday 16.12. 09:00 - 10:30 UZA2 Hörsaal 4 (Raum 2Z221) 2.OG
  • Thursday 09.01. 10:30 - 12:00 UZA2 Hörsaal 4 (Raum 2Z221) 2.OG
  • Monday 13.01. 09:00 - 10:30 UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
  • Thursday 16.01. 10:30 - 12:00 UZA2 Hörsaal 4 (Raum 2Z221) 2.OG
  • Monday 20.01. 09:00 - 10:30 UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
  • Thursday 23.01. 10:30 - 12:00 UZA2 Hörsaal 4 (Raum 2Z221) 2.OG
  • Monday 27.01. 09:00 - 10:30 UZA2 Hörsaal 5 (Raum 2Z202) 2.OG
  • Thursday 30.01. 10:30 - 12:00 UZA2 Hörsaal 4 (Raum 2Z221) 2.OG

Information

Aims, contents and method of the course

the thermodynamic basis for interaction of drugs with biomolecules; interaction forces involved in drug-biomolecule interaction (ionic-, dipol-dipol-, electronendonor/acceptor-, hydrophobic-, Van der Waals-interactions, hydrogen bonding) and methods to measure these forces (microcalorimetrie, ORCD, binding studies), determination of the structure of ligand-protein complexes (X-ray crystallography, NMR-spectroscopy), strategies for identification of lead-compounds (serendipity, transition state mimicry, high throughput screening, in silico screening), optimisation of lead compounds - rational drug design (statistical background, 2D- and 3D- structure activity relationship analysis, methods used in quantitative structure activity relationship studies), structure based design (docking, SAR by NMR, de novo design)

Assessment and permitted materials

Written exam, 12 questions, 100 points, 90 minutes

Minimum requirements and assessment criteria

The lecture gives an overview on the theoretical background and the experimental biophysical methods for the rational design of new drugs. Main topics are the molecular basis of drug-receptor interaction, methods for measuring the corresponding interaction forces and the use of these data in computational drug design.

Examination topics

Language: German (material partly in English); powerpoint presentation, software demonstrations

Reading list

Association in the course directory

A210

Last modified: Sa 02.04.2022 00:27