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320029 VO Gen. principles of drug action & pharmakokinetics (2007S)
General principles of drug action and pharmakokinetics
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Beginn 06.03.2007
Di, Mi 12.30-14.00
Di, Mi 12.30-14.00
Details
Language: German
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Currently no class schedule is known.
Information
Aims, contents and method of the course
Assessment and permitted materials
Minimum requirements and assessment criteria
To describe the general principles of drug action with focus on cellular and molecular mechanisms and signal transduction cascades. The course includes the mechanisms of drug absorption, distribution and elimination and pharmacokinetics.
Examination topics
Reading list
Association in the course directory
A225
Last modified: Fr 31.08.2018 08:57
Drug-receptor-interactions, classification of different targets for drug action (receptors, ion channels, enzymes, carrier molecules), structure and functions of selected receptors (ligand-gated ion channels, G-protein-coupled receptors, nuclear receptors, kinase-linked receptors), pharmacology of second messenger systems (e.g. the adenylate cyclase/cyclic AMP system and the phospholipase C/inositol phosphate system), interaction of ion channels with G-proteins, the molecular architecture of voltage gated ion channels, their function and pharmacological properties, the release of chemical mediators, routes of drug administration, absorption, distribution, elimination (phase I reactions, the cytochrome P450 system), phase II reactions, first pass effect, active drug metabolites, renal excretion, pharmacokinetics (including compartment models), the autonomic nervous system (cholinergic and noradrenergic transmission, transmission by purines and 5-hydroxytryptamin), peptides and proteins as drugs, nitric oxide, local hormones.