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320050 VO Resistance in Tumortherapy (2006W)
Resistance in Tumortherapy - Mechanisms and Solutions
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Erstmals am 09.10.2006
Montag 17.00 - 18.30 Uhr
Montag 17.00 - 18.30 Uhr
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Aims, contents and method of the course
Assessment and permitted materials
Minimum requirements and assessment criteria
The lecture gives an overview on the mechanisms responsible for development of drug resistance in tumor therapy. Both specific mechanisms as well as the molecular basis oo multiresistance is discussed. Additionally, the development of drugs acting on resistant tumors or being able to modulate drug resistance is presented.
Examination topics
Reading list
Association in the course directory
N 2270
Last modified: Fr 31.08.2018 08:57
development of tumors, mechanisms of the most important classes of cytostatic agents, molecular basis for the development of specific mechanisms of resistance (overexpression of DNA-rapair enzymes, mutations of target proteins, overexpression or lack of enzymes responsible for metabolism/activation of cytostatic drugs, decreased influx); resistance against modulators of signal transduction pathways (kinase inhibitors, farnesyl transferase inhibitors); telomerase inhibitors, inhibition of angiogenesis, immunetherapy and genetherapeutic approaches; mechansims responsible for development of multiresistance, failures in apoptose pathways, overexpression of efflux proteins; structure and function of P-glycoprotein, substrates and inhibitors of efflux proteins, development of new modulators of multidrug resistance; analogous proteins in bacteria and fungi.