320051 VO Resistance in Tumortherapy (2008W)

development of tumors, mechanisms of the most important classes of cytostatic agents, molecular basis for the development of specific mechanisms of resistance (overexpression of DNA-rapair enzymes, mutations of target proteins, overexpression or lack of enzymes responsible for metabolism/activation of cytostatic drugs, decreased influx); resistance against modulators of signal transduction pathways (kinase inhibitors, farnesyl transferase inhibitors); telomerase inhibitors, inhibition of angiogenesis, immunetherapy and genetherapeutic approaches; mechansims responsible for development of multiresistance, failures in apoptose pathways, overexpression of efflux proteins; structure and function of P-glycoprotein, substrates and inhibitors of efflux proteins, development of new modulators of multidrug resistance; analogous proteins in bacteria and fungi.