320075 VO New Drugs (2005W)

Examples of drugs for the treatment of ophthalmic or skin diseases, which will be discussed in the lecture, are as follows:
" Bimatoprost, a Prostaglandin F2 -derivative, travoprost, a full agonist at the
prostaglandin FP-receptor, and brinzolamide, a topically active inhibitor of
carboanhydrase II, are used to lower the intraocular pressure in chronic open-
angle glaucoma and in ocular hypertension
" Verteporphin, a photosensitizer, which is suited for photodynamic therapy of
chorioidal neo-vascularizations
" Temoporphin, another photosensitizer, is applied in the photodynamic tumour-
therapy, for instance in certain cases of precancerous lesions and malignant
tumours of the skin
" Imiquimod is suited for the local therapy of Condylomata acuminata in the genital
and anal regions
" the immunsuppressive agents Pimecrolimus and Tacrolimus are important
additions to the topical treatment of atopic dermatitis
" Eflornithin, an irreversible inhibitor of the ornithin-decarboxylase, which is
registered for the treatment of hirsutism in the face of women
ECTS-points: 1.1