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320152 PR Drug analysis and drug development (2012S)
(6 Kurse)
Continuous assessment of course work
Labels
Endbesprechung PCR Beispiel am 16.11.2012 ab 18.00 Uhr im HS 4 UZA II!!
Details
Language: German
Lecturers
- Ernst Urban
- Andrea Deutsch
- Mehrdad Dirin
- Gerhard Ecker
- Christiane Gebhard
- Andreas Jurik
- Freya Klepsch
- Martin Kratzel
- Bodo Lachmann
- Petra Memminger
- Sebastien Queva
- Michael Sonntagbauer
- Martina Stessl
- Elisabeth Strizsik
- Johannes Winkler
- Georg Anton Mühlbacher (Student Tutor)
Classes (iCal) - next class is marked with N
- Friday 16.11. 18:00 - 19:00 UZA2 Hörsaal 4 (Raum 2Z221) 2.OG
Information
Aims, contents and method of the course
Assessment and permitted materials
Minimum requirements and assessment criteria
Teaching aim:Main objective: Knowledge how to guarantee the pharmaceutical quality of drugs and how to identify and optimize drugs. Experience in handling the instruments used in quantitative analysis and syntheses; knowledge on computer assisted drug design; development of the ability for method selection, practical running, evaluation and documentation of analytical results.
Examination topics
Reading list
Association in the course directory
A303
Last modified: Sa 02.04.2022 00:27
A: Quantitative determination of active substances in drugs (single compounds, mixtures, impurities) with instrumental methods:
Methods: Spectrophotometry, conductometry, potentiometry, amperometry, polarography, polarimetry, ion selective measurement, water content according to Karl-Fischer, HPLC with refraction index, UV, and fluorescent detection, capillary electrophoresis, enzymatic methods.
Studies concerning the pharmaceutical quality of active ingedients: identity, content, purity, impurity profile; determination of a drug with three selected methods (teamwork), validation of the analytical methods, statistical evaluation, GLP analysis, and discussion of methods and results.
B. Analytical, in silico and special synthetic methods in drug design (lead structure finding and lead structure optimization):
Genome und proteome analysis; biophysical pharmaceutical chemistry (microcalorimetry, ORCD measurements), in vitro and in silico interaction studies, molecular modeling, analysis of structure activity relationships, special synthetic methods (libaries by parallel or combinatorial solid phase synthesis, peptide synthesis, and oligonucleotide synthesis), documentation (chemical part of a "drug master file" - general, synthesis, analysis).