322573 VU Drug Delivery to the Lungs - M7/M14 (2022S)

Lecturers

• Gabriela Hädrich

Classes

Locations will be posted on the Moodle website
Mo - 30.05.2022 - 9:30 -11:30 Uhr - Forschungspräsentation - HS6
Opening Lecture - Prof. Dr. Carsten Ehrhardt, Trinity College Dublin, Galenus Guest Professor

The Biopharmaceutics of ABC Transporters in the Lung

Virtually every cell in the body is equipped with a tightly regulated machinery of membrane transporter proteins. These transporters facilitate cellular entry or efflux of their substrates across lipid bilayer membranes. Efflux transporters, which often require primary or secondary metabolic energy to function, have important physiological roles in maintaining barrier function and cellular detoxification and clearance. In the context of drug delivery, however, the protective function of efflux transporters sometimes negatively impacts on bioavailability, in cases where the drug in question is a substrate for such transporters. This can lead to reduced gastrointestinal absorption, increased hepatic and/or renal clearance and restricted access to certain compartments, such as the CNS. Moreover, upregulated transporter expression in cancer cells can result in resistance of tumours to chemotherapy.

Whilst a wealth of information has been published on transporter effects in drug disposition in the gut, liver, kidneys and the blood-brain-barrier, pulmonary transporter research remains a relatively poorly understood area of research. This presentation will discuss the expression of relevant members ATP-binding cassette (ABC) transporter family, namely, P-glycoprotein (P-gp), multidrug resistance-associated protein 1 (MRP1) and breast cancer resistance protein (BCRP) in the lung and in addition, will highlight the clinical impact these efflux transporters can have on pulmonary cell physiology, detoxification and drug disposition.
Thur - 02.06.2022 -9:30 -11:30 - Introduction - 2F317
Fri - 03.06.2022 - 9:30 - 11:30 - Lab groups I/II - 2E165
Wed - 08.06.2022 - 9:30- 11:30 - Lab groups III/IV - 2E165
Fri - 10.06.2022 - 9:30-11:30 - Data analysis - 2D404

Fri - 17.06.2022 - Deadline for submission of lab report - MOODLE